Curriculum Vitae`

Curriculum Vitae

Vishwesh Haricharan Rai

✉ vishweshraichemie@gmail.com/ vishwesh.rai@protonmail.com	🧔Male 📅19.09.1992
🌏Pusad (Maharashtra, 445204)	📱+91 898X XXX 851
🎓Acad. specialisation (completed): Chemical Engg (MTech)	Univ.: Indian Institute of Technology Bombay
🖆Acad. specialisation (ongoing): Chemical Engg (PhD)	Univ.: Indian Institute of Science Bangalore

 🎓 ACADEMIC QUALIFICATIONS

	University	Institute	Year	CPI / %
Post-Graduation	IIT Bombay	IIT Bombay	2017	9.41
Undergraduate Specialization: Chemical Engineering
Graduation	VNIT Nagpur	VNIT Nagpur	2015	8.58

🔬 DOCTORAL RESEARCH (ongoing)

🔮 Prof Rahul Roy’s Group (Nanobiophotonics Lab), Dept of Chemical Engineering

[Oct 2020 onwards]

🧪 Pore-forming Toxins – Assembly Dynamics (ongoing)

Studying the process of assembly of PFTs on artificial lipid-bilayers using single-molecule experiments

🧫 Dynamics in Crowded Membranes (ongoing)

Elucidating crowders' effect on binding, assembly, and fusion dynamics of biologically important moieties with artificial lipid bilayers using single molecule experiments

🧬 DNA Origami (ongoing)

Designing and synthesising biomimicking DNA-nanostructures using novel origami for studying membrane-biomolecule dynamics; design and assembly of origami-based vectors for RNA delivery.

🗠 PUBLICATIONS

✒ Sannigrahi, Achinta, Vishwesh Haricharan Rai, Muhsin Vannan Chalil, Debayani Chakraborty, Subrat Kumar Meher, and Rahul Roy. 2022. "A Versatile Suspended Lipid Membrane System for Probing Membrane Remodeling and Disruption" Membranes 12, no. 12: 1190. https://doi.org/10.3390/membranes12121190

✒ Maurya S, Rai VH, Upasani A, et al. Single-molecule Diffusion and Assembly on Polymer-crowded Lipid Membranes. Journal of Visualized Experiments: Jove. 2022 Jul (185). DOI: 10.3791/64243. PMID: 35938845.

🏭 PROFESSIONAL EXPERIENCE

Pos.: Assistant Manager	Engineering Projects – Process Design [Jul 2017 – Mar 2020]
Organisation:	Biocon Biologics India Ltd.

Role: Engineering design, procurement, commissioning, and qualification of API manufacturing (chemical synthesis) facility set up by M/S Syngene International Ltd. at Mangalore SEZ. Responsible for design verification at the post-detailed engineering stage, tendering for process equipment, technical and commercial analysis of bids, and execution of installation, commissioning, and qualification activity for the facility.

📌 PROJECTS AND INTERNSHIPS

📊 MASTER’S THESIS PROJECT

💉Aerosol synthesis of lipid encapsulated nanoparticles for intrapulmonary delivery of insulin.

[Jan 2016 – Jul 2017]

Conducted comprehensive research on commercial inhaled insulin-delivery systems, analyzing their features and limitations compared to injectable insulin. Developed lipid encapsulated nanoparticles through aerosol synthesis for efficient intrapulmonary insulin delivery. Achieved optimal bioavailability, biocompatibility, and patient compliance by synthesizing nanoparticles with aerodynamic sizes of 50 to 200 nm and encapsulating insulin in a crystalline lipid shell. Utilized air-jet atomization to form nanoparticles from a precursor solution. Carried out in-depth characterization of the synthesized particles using TEM and FTIR for substructure and surface composition analysis, respectively. Conducted in-vitro studies to evaluate insulin release in PBS, measuring insulin concentration with a fluorescence spectrophotometer. Thus, developed an innovative approach for intrapulmonary insulin delivery with potential clinical significance.

👷 SUMMER INTERNSHIPS AND BACHELOR’S THESIS PROJECT

Organisation	Project
NIT Nagpur and NEERI Nagpur	⚗ Study of extractive distillation of MCH and toluene using NMP	[May – Jun 2013]
		Surveyed and studied the VLE properties of the MCH/Toluene system and determined N-methyl-2-pyrrolidone as a suitable solvent for extractive distillation of MCH/Toluene. Theoretically calculated the separation efficiency for a system using McCabe-Thiele Method.
NIT Nagpur	🖥 Simulation of manufacturing of nanocatalyst using ASPEN Plus®	[Jul 2014 – Apr 2015]
		An attempt was made to model and simulate the manufacturing process of heterogeneous nanocatalyst MCM41 from rice husk using the basic ASPEN Plus package of ASPEN Plus®.

🧮 MINI PROJECTS

Finding the optimal drying conditions by solving a set of non-linear ODEs using the finite element method and MATLAB® programming (Prof Madhu Vinjamur) Generated the temperature-time history for drying polymeric rods using MATLAB® (ODE45) for different convective heat transfer coefficients and rod radii. Determined the temperature-induced radial stresses in the rod at different times and determined the optimum radius and heat-transfer coefficient for the same.

Simulation of packed bed reactor with side streams using COMSOL® (Prof Vinay Juvekar) Simulated a packed bed catalytic reactor with a side stream of one of the reactants (at steady state) for radial and longitudinal concentration profiles.

Review Study: Role of Mechanical forces in embryonic development (Dr Abhijit Majumder) Reviewed the roles played by various mechanical forces in embryonic development and the effects of imbalance of these forces leading to different congenital disorders.

💻 SOFTWARE SKILLS

● C/C++ ● MATLAB® ● Python 3 ● Mathematica® ● COMSOL® ● ASPEN Plus®

🛑 END 🛑